Its principal mandate is to design and implement public health programs and research studies that benefit vulnerable populations, especially young people and women in Kenya.
To understand the multiple ways in which gender-based violence (GBV) impacts the effective use of oral pre-exposure prophylaxis (PrEP) by adolescent girls and young women (AGYW) in Siaya County, Kenya, and to develop and pilot test and intervention to increase PrEP uptake and adherence in AGYW who experience GBV.
The study consists of mixed-methods formative research (Aim 1), which will inform the development of an intervention. The intervention will be pilot-tested to assess feasibility, safety, and preliminary effects through a pilot cluster randomized-controlled trial (RCT) (Aim 2).
The study is being guided by two specific aims, as outlined below.
Study Specific Aims: Aim 1. To characterize patterns of PrEP uptake and adherence among young GBV survivors, and to understand their unique barriers and facilitators to PrEP use, by means of mixed-methods formative research.
Aim 2. To implement and assess the feasibility, safety, and preliminary effects of the resulting intervention through a pilot cluster randomized-controlled trial (RCT) with 100 AGYW.
THE STUDY IS ABOUT
- To improve the continuum of HIV prevention and care and treatment within KPs programs by:-Optimal adherence to scheduled clinic appointments and retention of FSWs and MSMs at the DiCEs.
- Text For Adherence (T4A) monitor adherence of FSWs and MSMs to quarterly clinic appointments over 18Months period, an intervention of Telegram messaging coupled with 2 Way SMS reminders sent to participants:
-1 day to clinic appointment
-7 days after missed appointment
Determine whether providing multiple self-tests to high-risk, HIV-uninfected women can promote HIV testing in their sexual networks, facilitate safer sexual decision-making, and reduce the women’s risk of acquiring HIV
It is a Cluster randomized trial where 66 geographic clusters randomly selected in the ration of 1:1. About 30 HIV-negative adult women enrolled per cluster which were selected by mapping beach communities and hotspots (bars/restaurants) in Siaya County.
This formative study will establish a prospective cohort of HIV infected adolescents at high-volume HIV care clinics in Western Kenya to determine correlates of retention and viral suppression (Aim 1). These data will inform creation of an age and developmentally-appropriate clinical prediction tool for health care workers (HCWs) to target resources towards youth most in need (Aim 2). Qualitative interviews and focus group discussions (FGDs) will assess ethical and legal considerations for adolescent participation in HIV care and research (Aim 3). These aims will inform development of a health services intervention using a data-driven, stepped care approach to promote AYA retention in HIV care.Read More